The increasing number of cyclists, and the introduction of new infrastructure has created new ways for cyclists and other road users to interact, which may impact road safety. Consequently, our aim was to contribute to a better understanding of accidents involving cyclists through an in-depth, pre-accident analysis based on an activity-centred approach. Various pre-accident situations, judged as risky by twenty cyclists, were collected and classified as a function of their relative frequency of occurrence. The analysis found that a third of these situations involved interactions with pedestrians or other obstacles. Then, the most frequent situations are related to: (a) interactions with motorists either entering or leaving a parking space; (b) motorists who stepped in front of a cyclist when turning right; (c) cars entering the road from the right at an intersection, and (d) motorists squeezing cyclists off the road when overtaking. An analysis of situations where cyclists’ visibility was impaired found similar results except for situations (c) and (d) where cyclists’ visibility was very rarely engaged, and which both appeared to be associated to deliberate motorist behaviours. These findings point out the most frequent pre-accident situations reported by cyclists, and highlight the need for their better integration, as a new type of road user, in urban areas.